In response to the recent HIV epidemic among people who inject drugs (PWID) that began in Athens following austerity measures in 2010, this intervention attempts to model a targeted, network-based, public health Pre-Exposure Prophylaxis (PrEP) intervention. Building upon recent phylogenetic and surveillance analysis identifying network members who “bridge” PWID and MSM communities, this study will map these bridging networks, measure early PrEP outcomes (ie. PrEP linkage-to-care), and model the effects of a targeted public health PrEP intervention on HIV transmission in Athens. Given the limited resources for public health interventions, it is our hope that model-based analyses such as these can identify and test intervention strategies in order to maximize the impact on emerging and reemerging HIV epidemics globally.